Official specs from Steam

Grand Theft Auto: San Andreas - The Definitive Edition system requirements

Minimum and recommended PC specs as listed by the developer on Steam.

Minimum

NoteRequires a 64-bit processor and operating system
OSWindows 10
ProcessorIntel® Core™ i5-6600K / AMD FX-6300
Memory8GB GB RAM
GraphicsNvidia GeForce GTX 760 2GB / AMD Radeon R9 280 3GB
Storage19 GB available space
Sound CardDirect X Compatible

Recommended

NoteRequires a 64-bit processor and operating system
OSWindows 10
ProcessorIntel® Core™ i7-6600K / AMD Ryzen 5 2600
Memory16 GB RAM
GraphicsNvidia GeForce GTX 970 4GB / AMD Radeon RX 570 4GB
Storage19 GB available space
Sound CardDirect X Compatible

FAQ

What graphics card do I need for Grand Theft Auto: San Andreas - The Definitive Edition?

Minimum: Nvidia GeForce GTX 760 2GB / AMD Radeon R9 280 3GB. Recommended: Nvidia GeForce GTX 970 4GB / AMD Radeon RX 570 4GB.

How much RAM does Grand Theft Auto: San Andreas - The Definitive Edition need?

Grand Theft Auto: San Andreas - The Definitive Edition needs 8GB GB RAM at minimum, 16 GB RAM recommended.

How big is Grand Theft Auto: San Andreas - The Definitive Edition?

Grand Theft Auto: San Andreas - The Definitive Edition requires 19 GB available space.

Does Grand Theft Auto: San Andreas - The Definitive Edition run on Mac or Steam Deck/Linux?

There is no native macOS version. There is no native Linux build (Proton compatibility may vary).