Official specs from Steam

I Have No Mouth, and I Must Scream system requirements

Minimum and recommended PC specs as listed by the developer on Steam. Native macOS version available. Native Linux build available.

Minimum

OS *Windows 7 / 8.1 / 10
ProcessorIBM PC with a 233Mhz 486 processor
Memory64 MB RAM
GraphicsA VESA compatible Super VGA card
DirectXVersion 9.0c
Storage2 GB available space
Sound CardSound Blaster AWE32 sound card

Recommended

OSWindows 10
ProcessorIBM PC with a 486 DX2/ 66Mhz (or faster) processor
Memory128 MB RAM
GraphicsA VESA compatible Super VGA card
DirectXVersion 9.0c
Storage2 GB available space
Sound CardSound Blaster AWE32 sound card

macOS minimum

OSMac OS X 10.6.8
ProcessorIBM PC with a 233Mhz 486 processor
Memory64 MB RAM
GraphicsA VESA compatible Super VGA card
Storage2 GB available space
Sound CardSound Blaster AWE32 sound card

macOS recommended

OSMac OS X 10.7 or newer
ProcessorIBM PC with a 486 DX2/ 66Mhz (or faster) processor
Memory128 MB RAM
Sound CardSound Blaster AWE32 sound card

FAQ

What graphics card do I need for I Have No Mouth, and I Must Scream?

Minimum: A VESA compatible Super VGA card. Recommended: A VESA compatible Super VGA card.

How much RAM does I Have No Mouth, and I Must Scream need?

I Have No Mouth, and I Must Scream needs 64 MB RAM at minimum, 128 MB RAM recommended.

How big is I Have No Mouth, and I Must Scream?

I Have No Mouth, and I Must Scream requires 2 GB available space.

Does I Have No Mouth, and I Must Scream run on Mac or Steam Deck/Linux?

Yes, there is a native macOS version. A native Linux build is available.